Bouganivillea Spectabilis as herbal medicine to control blood sugar levels of albino mice/ (Record no. 16583)

000 -LEADER
fixed length control field 03474nam a22002657a 4500
001 - CONTROL NUMBER
control field 16583
003 - CONTROL NUMBER IDENTIFIER
control field OCLRC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20260731013039.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250809t xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency OCLRC
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number (Call Number) T 610.73 2024 1569
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Barrera, Sofia Elaine L.
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name De Guzman, Jean Lexy P.
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Del Rosario, Mary Mathel P.
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Parreño, Alyssa B.
245 ## - TITLE STATEMENT
Title Bouganivillea Spectabilis as herbal medicine to control blood sugar levels of albino mice/
Statement of responsibility, etc. Sofia Elaine L. Barrera, Jean Lexy P. De Guzman, Mary Mathel P. Del Rosario, Alyssa B. Parreno
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication, distribution, etc. Parañaque City:
Name of publisher, distributor, etc. Olivarez College,
Date of publication, distribution, etc. 2024.
502 ## - DISSERTATION NOTE
Dissertation note Undergraduate thesis.
520 ## - SUMMARY, ETC.
Summary, etc. The prevalence of Diabetes Mellitus remains a significant health concern globally, prompting the exploration of alternative treatments such as herbal medicines. Bougainvillea spectabilis, commonly known as Bugambilya, is one such plant believed to possess bioactive compounds with hypoglycemic effects. Phytochemical analysis of its leaves has identified various compounds including sterols, flavonoids, saponins, glycosides, and tannins. As Bougainvillea is widely available and accessible, this study investigates its potential as a cost-effective remedy for high blood sugar levels. Acquired and conducted in the Laboratory Animal Facility of the Department of Science and Technology (DOST), thirty (30) alloxan-induced diabetic male albino mice aged 8-12 weeks were divided into six treatment groups: Negative Control (PNSS), Positive Control (Insulin glargine), and four doses of Bougainvillea leaves extract (T1: 2000mg/kg, T2: 1500mg/kg, T3: 1000mg/kg, T4: 500mg/kg). The hypoglycemic activity of methanol extract of Bougainvillea leaves was monitored for the first five (5) hours post-administration. Results revealed a distinct pattern in the 500 mg/kg dose, showing an initial decrease in blood sugar levels in the first hour, contrasting with an increase observed in other treatments. Additionally, the 500 mg/kg dose exhibited a subsequent increase in the second hour, while other treatments displayed a decrease. In addition to this, from the third to fourth hour, all treatments consistently decreased blood sugar levels in male albino mice. Remarkably, 2000 mg/kg dose showed a significant decrease from third (3rd) to fifth (5th) hour. Despite Bougainvillea spectabilis leaves extract demonstrating hypoglycemic effects, Insulin glargine induced a more radical change in blood sugar levels. Statistical analysis using one-way ANOVA and TUKEY Honest Significant Difference (HSD) Test indicated significant differences in blood sugar levels among treatments during the first three hours post-administration. Having these findings, Bougainvillea spectabilis leaves extract showed a potential hypoglycemic effect on alloxan-induced diabetic male albino mice, suggesting its potential as a candidate for the development of new herbal medicines. Further investigation is warranted to explore its therapeutic potential using different dosages and in vivo experimental subjects. This research could contribute to a deeper understanding of the mechanisms underlying its hypoglycemic activity and its suitability for clinical applications in managing diabetes mellitus.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Subject Entry extract.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Subject Entry phytochemicals.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Subject Entry hypoglycemic.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Subject Entry in vivo experimental diabetes mellitus.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Theses/Dissertation
Location (call number prefix code) T 610.73 2024 1569
Holdings
Withdrawn status Lost status Piece physical condition (Damaged Status) Not for loan Home library Current library (holdingbranch) Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
        Olivarez College Learning Resource Center General Reference And Serial Section 07/31/2026   T 610.73 2024 1569 07/31/2026 07/31/2026 Theses/Dissertation