Antiangiogenic Activity of the Spermatheca Gland Extract of Hornsnails (Telescopium telescopium) using Chick Chlorioallantoic Membrane (CAM) Assay (Record no. 16727)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03542nam a22003377a 4500 |
| 001 - CONTROL NUMBER | |
| control field | 16727 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OCLRC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260731013043.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 260127t xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | OCLRC |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number (Call Number) | T 610.73 2024 1577 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Bravo, Devee Rose D. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abesamis, Andrea Isabelle B. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Labiran, Via |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Arrojado, Edsan Nicole D. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tiongco, Ian Kyle B. |
| 245 ## - TITLE STATEMENT | |
| Title | Antiangiogenic Activity of the Spermatheca Gland Extract of Hornsnails (Telescopium telescopium) using Chick Chlorioallantoic Membrane (CAM) Assay |
| Statement of responsibility, etc. | Devee Rose D. Bravo, Andrea Isabella B. Abesamis, Via Labiran, Edsan Nicole D. Arrojado and Ian Kyle B. Tiongco |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | Paranaque City: |
| Name of publisher, distributor, etc. | Olivarez College, |
| Date of publication, distribution, etc. | 2025. |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Undergraduate thesis, |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In the Philippine Cancer Societys (PCS) registry data, approximately 59,000 people die of cancer annually, highlighting the need for research into mechanisms driving cancer progression, such as angiogenesis-the formation of new blood vessels. Marine organisms, particularly mollusks, have shown promise in medicine, with compounds from these species contributing to various therapeutic areas. The objective of this study was to determine the antiangiogenic activity of the Spermatheca gland of Hornsnail (Telescopium telescopium), collected from the Bulungan Seafood Market - Paranaque Fish Port, using Chick Chorioallantoic Membrane (CAM) Assay. Telescopium Spermatheca Extract (TSE) was subjected to modified levels of Phosphate Buffered Saline (PBS) concentration. Three treatment groups, negative control, blank control PBS solution, and TSE-were used for the CAM assay. Biochemical screening analysis was also done for the extract. Among the treatment groups, 1000 μL of 10 mg/mL TSE showed the highest inhibition percentage of blood vessel growth. Moreover, there is no significant difference in blank control. Biochemical screening analysis confirmed the presence of Carbohydrates, Proteins, Sterols, and Alkaloids in the extract, which may contribute to the observed antiangiogenic properties. Quantitative analysis of the blood vessels revealed that 1000 μL 10mg/mL of the TSE treatment group exhibited the highest inhibition percentage, demonstrating a significant reduction in blood vessel growth compared to the negative control. This suggests that the extract possesses strong antiangiogenic properties. Notably, the effect showed no significant difference from the blank control, indicating that the suppression of blood vessel formation may be concentraton dependent. The 0.5 mL extract treatment exhibited even more significant suppression, suggesting that a lower concentration might be more effective in inhibiting angiogenesis. The Spermatheca Gland crude extract resulted in a positive inhibition of compounds, demonstrating inhibition of angiogenesis-a significant reduction in the length of blood vessels- with a p-value of 0.000003 at a level of significance of α < 0.05. The number of blood vessels has Pv=0.00157 at level of significance α < 0.05. On the other hand, Sterols were also assumed to be the main biochemical class constituent of the antiangiogenic compound of interest. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Subject Entry | Sterols. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Subject Entry | Alkaloids. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Subject Entry | Animal Pharmacology. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Subject Entry | Proteins. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Subject Entry | Egg Incubation. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Subject Entry | Duck Eggs. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Subject Entry | Mollusk. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Subject Entry | Blood Vessels. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Subject Entry | Anticancer agent. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Theses/Dissertation |
| Location (call number prefix code) | T 610.73 2024 1577 |
| Withdrawn status | Lost status | Piece physical condition (Damaged Status) | Not for loan | Home library | Current library (holdingbranch) | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Olivarez College Learning Resource Center | General Reference And Serial Section | 07/31/2026 | T 610.73 2024 1577 | 07/31/2026 | 07/31/2026 | Theses/Dissertation |